Bacteriium features and the drug resistance in lower respiratory tract infection patientsin respiratory and ICU departments

Objective:To evaluate the pathogens spectrum and drug-resistance rates of bacteria isolated from lower respiratory tract infection patients in respiratory and ICU departments.Methods:Clinical data of 307 bacterial strain with lower respiratory tract infection from October 2008 to September 2009 were reviewed.The pathogen types and antibiotic sensitivity of pathogens isolated from cultured sputum collected from the patients were analyzed.Make vital statistics by SPSS 17.0 software.Results:Gram-negative bacteria was a major pathogen,Acinetobacter baumannii ranked first(25.4%,78/307),followed by Pseudomonas aeruginosa(19.5%,60/307),k.pneurnoniae(12.4%,38/307),Methicillin-resistant Staphylococcus aureus is the main croorganism in Grampositive cocci(7.2%,22/307).The effective agents against Gram-negative bacteria were Imi-penem/Cilastati,Cefoperazone/sulbactam,levofloxacin etc.;Grampositive cocci,especially the Methicillin-resistant Staphylococcus aureus were against Azithromycin,clarithromycin,Penicillin,Ofloxacin,but it was sensitive to Vancomycins,Linezolids.Conclusion:Gram-negative bacteria are the main pathogen in pneumonia.the rate of drug-resisted is high,especially in ventilator-associated-pneumonia,we should take appropriate measures to actively prevent.