SAT0324 SEXUAL HEALTH IN WOMEN AND MEN WITH SYSTEMIC SCLEROSIS: A CROSS-SECTIONAL STUDY

Background: Systemic sclerosis (SSc) is a chronic multisystem disease that may affect all aspects of life including sexual function. Objectives: To assess sexual function, pelvic floor function in 80 women and 14 men with SSc compared to age-/sex-matched healthy controls (HC) and to analyze the potential impact of clinical features on sexual health. Methods: In total 80 women (mean age: 49, disease duration: 6.1 years, lcSSc/dcSSc: 53/27, mRSS: 9.3, ESSG activity index: 2.1) and 14 men with SSc (mean age: 51.6, disease duration: 3.1 years, lcSSc/dcSSc: 6/8, mRSS: 12.9, ESSG activity index: 2.2) who fulfilled the ACR/EULAR 2013 criteria, filled in 12 well-established and validated questionnaires assessing sexual function, pelvic floor function, quality of life, fatigue, physical activity and depression. Full names of questionnaires are listed in Table 1. These questionnaires were also completed by 80 healthy women and 14 healthy men with identical age. Data are presented as mean±SEM. Results: Compared to HC, women with SSc had significantly higher prevalence and greater severity of sexual dysfunction [FSFI total score (SSc: 16.4±1.3, HC: 25.6±1.2, p Conclusion: Both women and men with SSc reported significantly impaired sexual function compared to HC with identical age. Worse scores in SSc were associated with disease activity, increased systemic inflammation, health status, physical activity, fatigue and depression. Acknowledgments : Supported by MHCR 023728, SVV 260373 and GAUK 1578119. Disclosure of Interests: Barbora Heřmankova: None declared, Maja Spiritovic: None declared, Hana Smucrova: None declared, Sabina Oreska: None declared, Hana Storkanova: None declared, Kristyna Bubova: None declared, Karel Pavelka Consultant of: Abbvie, MSD, BMS, Egis, Roche, UCB, Medac, Pfizer, Biogen, Speakers bureau: Abbvie, MSD, BMS, Egis, Roche, UCB, Medac, Pfizer, Biogen, Jiři Vencovský: None declared, Ladislav Senolt: None declared, Radim Becvař Consultant of: Actelion, Roche, Michal Tomcik: None declared