Relation of C19 steroid sulfates in cord plasma to maternal urinary estriol

Abstract Estriol precursors were determined in the cord plasma of normal infants and in infants whose mothers had decreased gestational estriol. In affected infants dehydroisoandrosterone sulfate and 16α-hydroxydehydroisoandrosterone sulfate were markedly decreased. The role of fetal C 19 precursors in estriol biogenesis is discussed.