Synthesis of 1,6-Anhydro-2,3-di-O-farnesyl-5-O-(((phosphonomethyl) phosphinyl)methyl)-α-D-galactofuranose: A Zaragozic Acid- Presqualene Pyrophosphate Hybrid.

Abstract A multi-step synthesis of a new potential inhibitor (i.e., compound 2) of squalene synthase is described, starting from D-galactose. The title compound is a hybrid of presqualene pyrophopshate and the recently discovered zaragozic acids, which are picomolar competitive inhibitors of the enzyme squalene synthase.