Abstract 12132: A Genetic Risk Score is Associated With Atrial Fibrillation in the Malmö Prevention Project

Introduction: Atrial fibrillation is associated with increased morbidity and mortality. A genetic risk score (GRS) comprising 12 single nucleotide polymorphisms (SNPs) has been found to be associated with atrial fibrillation in population-based prospective studies of middle aged participants but this association has not been investigated in the elderly. Hypothesis: A pre-specified GRS for atrial fibrillation is associated with incident atrial fibrillation in the elderly. Methods: The Malmo Prevention Project (MPP) is a population-based prospective study of 18,240 participants who were enrolled in the study between 2002 and 2006. After excluding those with prevalent atrial fibrillation or missing clinical information 4,678 participants (median age of 68.2 years (IQR 66.5 to 73.0)) were randomly selected from the cohort for the current analysis. Cox proportional hazards models were used to estimate the association between GRS and incident atrial fibrillation after adjustment for age, sex, body mass index, s...