Molecular Genetics and Epidemiology of Prostate Carcinoma

I. Introduction A. Prostate carcinoma epidemiology: mortality rates, incidence, and prevalence B. Familial clustering of prostate carcinoma C. Scope of the review II. Somatic Genetic Alterations in Prostate Carcinoma A. Alterations in DNA methylation B. The androgen signaling cascade C. Vitamin D and prostate carcinoma D. Oncogenes E. TSGs F. Metastasis suppressor genes (MSGs) G. Telomerase activity III. Etiology of Familial Clustering of Prostate Carcinoma IV. Human Papillomavirus and Prostate Carcinoma V. Morphological Diversity of Prostate Carcinoma VI. Concluding Remarks