An efficient and green preparation of 5-aminophosphonate substituted pyrimidine nucleosides under solvent-free conditions
2010
Abstract An environmentally benign and highly efficient one-pot preparation of α -aminophosphonates under solvent-free conditions was developed. By employing this method, 5-aminophosphonate substituted pyrimidine nucleosides were synthesized in good to excellent yields starting from 5-formyl-2′-deoxyuridine, aniline and dimethylphosphite.
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