Prognostic value of the triglyceride-glucose index among non-diabetic patients with acute myocardial infarction in one year follow-up.

Background The triglyceride-glucose index (TyG index) is a novel metabolic marker initially used as an indicator of insulin resistance. Recently, its use as a cardiovascular risk factor has been taken into consideration; however, there is a shortage of evidence for its clinical importance. Aim The aim of the study was to assess the relationship between the TyG index = ln (fasting triglyceride [mg/dl] × fasting glucose [mg/dl]/2) and the incidence of major adverse cardiovascular events (MACE) in one year follow-up among non- diabetic patients with acute myocardial infarction (MI). In addition, the predictive value of the TyG index concerning all-cause mortality in the study group was evaluated. Methods For the study, 1340 non-diabetic patients with acute MI (median age 67 years, 70.4% male) were consecutively enrolled between 2013 and 2019. Fasting lipid profile and fasting glucose level were assessed within 24 hours of admission. Results MACE occurred in 8.13 % (n = 109) of the study group, whereas one year mortality rate was 14.5% (n = 195). There was no difference in the median TyG index value among patients with and without incidence of MACE in one year follow-up (8.73 [8.36-9.08] vs 8.81 [8.5-9.17], P = 0.09). Moreover, the TyG index was not a predictor of these events (P = 0.06). In multivariable regression analysis, only previously diagnosed coronary artery disease (CAD) was an independent predictor of MACE (OR, 1.54; 95% CI, 1.02-2.32; P = 0.03). Finally, the TyG index was not an indicator of all-cause mortality (P = 0.25). Conclusions The TyG index should not be used as a predictor of MACE and all-cause mortality among non-diabetic patients with MI in one year follow-up.