Therapeutische Effektivität von monoklonalen Antikörpern gegen Staphylococcus aureus in einem Sepsis- und Abszess-Mausmodell

The increased rates of resistance associated with antibiotic therapy against Staphylococcus aureus, the dominant cause for nosocomial infections has created renewed interest in using alternative treatment options. An antibody-based therapy approach as an emerging option for the prevention and treatment of serious staphylococcal infections is currently under prae-clinical and clinical investigation. In the presented study, the efficacy of passive immunotherapy was directly tested in vivo in two distinct mouse models of catheter-related sepsis and soft tissue infection. The proposed action of monoclonal antibodies is evoked by antibody-mediated phagocytosis. Overall, the results support the idea that implementation of antibodies to S. aureus can play a role for immunotherapy of staphylococci infections in humans.