Abstract 3664: Comparison of the Short-Form 12 to the Modified Rankin Scale Score at 3 and 12 Months Post Intracerebral Hemorrhage

Background: The modified Rankin Scale score (mRS) is routinely used to evaluate functional outcome following stroke. The Short Form 12 version 2 (SF-12v2) is a 2 minute physical and mental health survey that measures 8 domains of health and is: widely used, norm-based, and comprehensive. We sought to compare physical component summary (PCS) scores, mental component summary (MCS) scores, and their sub-scores to the mRS scores. Each metric provides unique and relevant health information. Methods: Consecutive ICH patients were prospectively enrolled in the Diagnostic Accuracy of MRI in Spontaneous Intracerebral Hemorrhage (DASH) study. Three month evaluations were done in clinic when possible, while 1-year evaluations were obtained via semi-structured telephone interviews. Responses were adjusted for age and gender based on published data. Physical functioning ([PF] ability to perform activities), limitation in the amount and types of physical activities to the point that less is accomplished than desired (role physical [RP]), mental health ([MH] feelings of anxiety and depression), and PCS scores were compared to the mRS and to each other as they have the highest internal consistency based on published data. Significant depressive symptoms was defined as >10 points (1 standard deviation) below the mean. Results: Seventy-nine ICH patients had the SF12v2 and mRS available for assessment: mean age 59±17 years and ICH volume 22±27cc. Physical functioning at 3 months was correlated with mRS as assessed by: the PCS (R 2 =0.39); PF (R 2 =0.56); and RP (R 2 =0.52). At 12 months the mRS was more correlated with each sub component score and the PCS (R 2 =0.53). Feelings of anxiety and depression were not correlated with either 3 or 12 month mRS (R 2 = 0.06 and 0.15 respectively). At 3 months 6 (14%) patients with a mRS ≤2 had signs of depression and 6 (19%) of patients with mRS 3-4 had signs of depression as assessed by MH. More patients with mRS ≥2 had depressive symptoms (22% vs 4%, p=0.09) at 3 months and at 12 months (14% vs 0%, χ 2 =4.7, p=0.04) compared to those with a mRS of 0-1. Conclusions: The self reported physical components of the SF12v2 have only a fair correlation with the mRS at 3 and 12 months after intracerebral hemorrhage. Feelings of depression do not have a linear relationship with mRS, but a higher proportion of patients with increased mRS have significant depressive symptoms at one year.