Multiomic Signature of Glaucoma Predisposition in Flammer Syndrome Affected Individuals – Innovative Predictive, Preventive and Personalised Strategies in Disease Management

The second leading cause of blindness in humans – glaucoma is a multi-factorial disease; risk factors known are highly complex. A genetic component plays a role in the glaucoma pathology as well as internal and external stress factors suggesting epi/genetic patho mechanisms of the disease. Liquid biopsy analyses have been demonstrated as relevant for detecting a specific glaucoma signature in Flammer Syndrome phenotype. Multiomic approach has been proven as being of great utility for predictive diagnosis of glaucoma and patient stratification, further, providing information for potential multi-target treatments tailored to the person. The chapter highlights the omic-technologies and comprehensive molecular biological output for innovative PPPM strategies in glaucoma research with a potential to improve medical services in the area.