Process method of synthesizing tenofovir alafenamide

The invention provides a process method of synthesizing tenofovir alafenamide. The tenofovir alafenamide is finally obtained through esterification, acylating chlorination, amidation and chiral splitting by taking (R)-9-(2-methoxyl propyl phosphate) adenine as an initial raw material. The process method provided by the invention is low in process cost, mild in reaction condition and simple and controllable in operating method, avoids use of a lot of toxic reagents, and is good in environment-friendly safety and stable in product quality.