[Significance of Tissue Factor-Bearing Microparticle Procoagulation Activity and Antithrombin III Detection in Thalassemia Patients].

题目: 地中海贫血患者组织因子微粒促凝活性及抗凝血酶Ⅲ检测的意义. METHODS: The TF+MP procoagulation activity was detected by chromogenic saubstract method, the levels of tissue factors (TF), tissue factor pathway inhibitor(TFPI), protein C (PC), protein S (PS), antithrombin Ⅲ(AT-Ⅲ), tissue plasminogen activator (tPA), thrombin-activated fibrinolysis inhibitor (TAFI), soluble E-selectin (sE-sel), intercellular adhesion molecule-1 (ICAM-1) and thrombomodulin (TM) were detected by ELISA in thalassemia group (n=71) and control group (n=20 heathy persons). RESULTS: Compared with control group, the AT-Ⅲ level decreased in β-thalastemia major group (TM) (P<0.05), the AT-Ⅲ level in TM group independeutly posstiody correlated with plt count (r=0.37, P<0.05); the levels of TF and sICAM in α-thalassenia intermediate group (TA) significantly decteased (P<0.05), the procoagulatim activity of TF+MP in β-thalassemia intermediate group (TI) increased sngnificantly (P<0.05)， moreover positively corretated with AT-Ⅲ level (r=0.77, P<0.05). The TF and sICAM-1 levels in normal liver functim group of Thalassemia patients were lower tham those in control group (P<0.01 and P<0.05, respectively), the TF+MP activity between normal and abnormal liver function was significantly different (P<0.05), while there were no significant difference in other correspoding indexes beween thalassemia group and control group as well as between each thalassemia groups. 结果: 重型β地中国贫组（TM组）AT-Ⅲ水平较对照组降低（P＜0.05），TM组AT-Ⅲ与Plt计数成独立正相关（rPLT=0.37，P＜0.05）；中间型α地中海贫血组（TA组）TF及sICAM-1水平较对照组显著降低（P＜0.01）；中间型β地中海贫血组（TI组）血浆TF+MP促凝活性较对照组显著增高（P＜0.05）并与AT-Ⅲ呈独立正相关（rAT-Ⅲ =0.77，P＜0.05）。地中海贫血患者肝功能正常组TF及sICAM-1水平较对照组降低（PTF＜0.01，PsICAM-1＜0.05），肝功正常组与非正常组间TF+MP活性有显著性差异（P＜0.05）；其余各组相应指标与对照组相比及组间相比无显著性差异。. 结论: 广西重型β地中海贫血患者有肝功能损害及抗凝物质的减少;中间型β自中海贫血患者血浆TF+MP的促凝活性异常增高；以上因素可能增加地中海贫血患者血液高凝状态或血栓形成的风险，但中间型α地中海贫血患者血浆sICAM-1及TF水平降低可能是中间型α地中海贫血患者及肝功正常患者抗血栓形成的保护性因素。.