Chapter 15:Retapamulin: a First-in-Class Pleuromutilin Antibiotic

The first mention of antibacterial activity of a pleuromutilin dates back to the early 1950s.1–3 In 1951 Kavanagh and colleagues from Columbia University and The New York Botanical Garden described for the first time a substance with antibacterial activity isolated from two basiomycetes species, Ple...