Selective modification of a native protein in a patient tissue homogenate using palladium nanoparticles
2019
We have developed new benign palladium nanoparticles able to catalyze the Suzuki–Miyaura cross-coupling reaction on human thyroglobulin (Tg), a naturally iodinated protein produced by the thyroid gland, in homogenates from patients’ tissues. This represents the first example of a chemoselective native protein modification using transition metal nanoobjects in near-organ medium.
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