Effect of ex vivo Expanded Recipient Regulatory T Cells on Hematopoietic Chimerism and Kidney Allograft Tolerance Across MHC Barriers in Cynomolgus Macaques

Raimon Duran-Struuck,Hugo P Sondermeijer,Leo Bühler,Paula Alonso‐Guallart,Jonah S. Zitsman,Yojiro Kato,Anette Wu,Alicia N. McMurchy,David C. Woodland,Adam Griesemer,Mercedes Martínez,Svjetlan Boskovic,Tatsuo Kawai,Cosimi Ab,Yong-Guang Yang,Zheng Hu,Cheng-Shie Wuu,Slate Ar,Markus Y. Mapara,Sam Baker,Rafal Tokarz,Vivette D. D'Agati,Scott M. Hammer,Marcus R. Pereira,Wi Lipkin,Thomas Wekerle,Megan K. Levings,Megan Sykes

Effect of ex vivo Expanded Recipient Regulatory T Cells on Hematopoietic Chimerism and Kidney Allograft Tolerance Across MHC Barriers in Cynomolgus Macaques

2017

Infusion of recipient regulatory T cells (Treg) promotes durable mixed hematopoietic chimerism and allograft tolerance in mice receiving allogeneic BMT with minimal conditioning. We applied this strategy in a Cynomolgus macaque model.

Keywords:

Chimera (genetics)
Immunology
Cynomolgus macaque
Diabetes mellitus
Major histocompatibility complex
Haematopoiesis
Allograft Tolerance
Ex vivo
Medicine
Kidney
Transplantation
T cell
FOXP3
Histocompatibility
Immunosuppression
Kidney transplantation
Transplantation Conditioning

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