Fluconazole-induced intoxication with phenytoin in a patient with ultra-high activity of CYP2C9
2010
Purpose
The cytochrome P450 enzyme CYP2C9 metabolizes several important drugs, such as warfarin and oral antidiabetic drugs. The enzyme is polymorphic, and all known alleles, for example, CYP2C9*2 and*3, give decreased activity. Ultra-high activity of the enzyme has not yet been reported.
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