Тромбоцитарное звено системы гемостаза и содержание гомоцистеина в сыворотке крови при коксартрозе

The aim of the investigation is to study the content of homocysteine in blood serum and the analysis of thrombocyte aggregation activity in patients suffering from degenerative-dystrophic diseases of coxofemoral joint (coxarthrosis). Materials and methods. There have been examined 155 patients with coxarthrosis and 45 healthy men and women aged 45-65 years old. The platelet aggregation ability has been studied using adenosine diphosphate (ADP) in small doses (1.25 mkg/ml) and collagen (2.0 mg/ml) as an aggregation inductor. Investigation material has been venous blood. Results. There has been found platelet tendency for hyperaggregation and of homocysteine increase in patients' blood, homocysteine concentration increase correlating positively with the increase of thrombocyte aggregation activity. These deviations are an additional factor promoting the development of thrombotic complications. Conclusion. Early detection of hyperhomocysteinemia and the increase of platelet aggregation activity as well as appropriate early therapy can be an important part of the prevention of postoperative thromboses in patients with hip pathology.