Method for improving reproducibility of rivaroxaban tablet dissolution curve
2014
The invention provides a method for improving reproducibility of a rivaroxaban tablet dissolution curve; the method comprises that through use of sodium dodecyl sulfate as a surfactant, a dissolution medium stock solution is prepared, wherein the content of sodium dodecyl sulfate in the dissolution medium stock solution is not allowed to be higher than 10%w/v; and micelles formed by sodium dodecyl sulfate in a dissolution medium are broken before use, sodium dodecyl sulfate is homogenized in the dissolution medium, and finally a dissolution rate test on the obtained dissolution medium is carried out. The method can effectively improve the reproducibility of the rivaroxaban tablet dissolution rate curve and provides a guarantee for accurate determination of the rivaroxaban dissolution rate.
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