N-phenyl-butenamidas with pharmaceutical properties.
1987
Compounds of formula (I) PHARMACEUTICAL PROPERTIES HAVE wherein X is R1 (HO) C = C (CN) -, R '' (CO) CH (CN) - or R1 and R2 are each hydrogen, or C1 -6 HIRE, R3, R4 and R5 are each hydrogen, hydroxy, halogen, nitro, cyano, carboxy, C1-4 alkyl, C1-4 alkoxy, C1-4 thioalkyl, C1-4 alkoxy HALO sUBSTITUTED, C1-4 thioalkyl HALO sUBSTITUTED, C2-5 alkoxycarbonyl, optionally substituted phenyl, optionally substituted phenoxy, R ', R "N- wherein R' 'YR" are each hydrogen or C1-4 alkyl OR "' CONH- where R" ' 'ES C1-4 alkyl, R6, R7 and R8 are each C1-6 alkyl, C1-6 alkyl substituted or FENIL HALO optionally substituted, or R6 and R7 TOGETHER WITH carbon atom to which they are attached form a cycloalkyl containing 3 to 7 carbon atoms, or R6 R7 and R8 TOGETHER WITH THAT carbon atom they are attached, they form a group bicycloalkyl containing 4 to 9 carbon atoms, and their salts.
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