Renal function in patients with pacemaker and diabetes

Summary Introduction. The key indicators for renal function are creatinine concentration and glomerular filtration rate. Implantation of a pacemaker in patients with dysfunction of electrical conduction system and diabetes impairs renal function. Aim. The influence of pacemaker on renal function in patients with diabetes. Material and methods. 92 patients were enrolled in the study, among whom 11 had diabetes. Each person was exam- ined before the procedure of pacemaker implantation, 24 hours and 48 hours after the procedure. Out of 92 patients 60 had implanted DDD pacemakers, 2 patients had VDD pacemakers and 30 patients had VVI pacemakers. All patients had GFR estimated with MDRD equation. After 24 and 48 hours the assessment of renal function was repeated. Results. GFR was not statistically significant after 24 hours after the procedure in patients with diabetes -5.09 ± 20.77 (p = 0.435 vs. values before the procedure) and 48 hours after the procedure -5.18 ± 16.73 (p = 0.328 vs. values before the procedure). Similarly, no significant change concerned GFR in patients without diabetes 24 hours and 48 hours after the procedure, and amounted to -1.17 ± 17.61 (p = 0.551 vs. values before the procedure) and -1.37 ± 17.22 (p = 0.476 vs. values before the procedure), respectively. Conclusions. Patients with diabetes and arrhythmias qualified for pacemaker implantation did not present with significant increase of glomerular filtration rate within 48 hours after the procedure in comparison with the values before the procedure. Both groups with and without diabetes did not present with significant increase of glomerular filtration rate in comparison with the values before the procedure.