Six2 functions redundantly immediately downstream of Hoxa2.
2008
Hox transcription factors control morphogenesis along the head-tail axis of
bilaterians. Because their direct functional targets are still poorly
understood in vertebrates, it remains unclear how the positional information
encoded by Hox genes is translated into morphogenetic changes. Here, we
conclusively demonstrate that Six2 is a direct downstream target of
Hoxa2 in vivo and show that the ectopic expression of Six2 , observed
in the absence of Hoxa2, contributes to the Hoxa2 mouse mutant
phenotype. We propose that Six2 acts to mediate Hoxa2 control over the
insulin-like growth factor pathway during branchial arch development.
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