Intramolecular Cyclization of Mannich Reaction for Synthesis of Pyrimido[2,1‐b]‐1,3,5‐thiadiazines.

H. A. H. El-Sherief,Zeinab A. Hozien,Ahmed El-Mahdy,A. E.-W. A. O. Sarhan

Intramolecular Cyclization of Mannich Reaction for Synthesis of Pyrimido[2,1‐b]‐1,3,5‐thiadiazines.

2011

H. A. H. El-Sherief
Zeinab A. Hozien
Ahmed El-Mahdy
A. E.-W. A. O. Sarhan

Reaction of 2-mercaptodihydropyrimidinones (I) with primary amines and formaldehyde in suitable solvent yields pyrimidothiadizinones (IV) (35 examples) via a double Mannich reaction.

Keywords:

Formaldehyde
Solvent
Mannich reaction
Intramolecular force
Chemistry
Organic chemistry
intramolecular cyclization

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