Prognostic Value of Blood Urea Nitrogen and Its Variations in Patients With Chronic Heart Failure

2010 
cohort of patients with PPCM. Methods: The Utah PPCM Registry was queried for eligible patients age $18 years with a confirmed diagnosis of PPCM (new reduced left ventricular ejection fraction (LVEF) #45%, no known etiology, diagnosed in the last month of pregnancy up to the 5 postpartum month). Patients were grouped according to recovery (LVEF #50%) (Rec) and no recovery (LVEF !50%) (NoRec). Echocardiographic measures of LVEF and left ventricular internal dimension at end-diastole (LVIDD) and medication use were tracked in both groups. Findings: 58 patients were included in the analysis. Average age was 30 years; 36 patients (62%) had recovery of cardiac function. The average time to recovery was 8.9 months. Echocardiographic measures and medication use between the groups are detailed (Table below). Conclusion: Patients with PPCM who have recovery of ventricular function are more likely to have a higher baseline LVEF, smaller left ventricular dimensions, and have increased use of standard heart failure medications. The neurohormonal antagonists studied here appear to have a meaningful impact on clinical characteristics for patients with PPCM and should be used as tolerated.
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