Accurate measurement of respiratory airway wall thickness in CT images using a signal restoration technique
2008
Airway wall thickness (AWT) is an important bio-marker for evaluation of pulmonary diseases such as chronic
bronchitis, bronchiectasis. While an image-based analysis of the airway tree can provide precise and valuable airway size
information, quantitative measurement of AWT in Multidetector-Row Computed Tomography (MDCT) images involves
various sources of error and uncertainty. So we have developed an accurate AWT measurement technique for small
airways with three-dimensional (3-D) approach. To evaluate performance of these techniques, we used a set of acryl
tube phantom was made to mimic small airways to have three different sizes of wall diameter (4.20, 1.79, 1.24 mm) and
wall thickness (1.84, 1.22, 0.67 mm). The phantom was imaged with MDCT using standard reconstruction kernel
(Sensation 16, Siemens, Erlangen). The pixel size was 0.488 mm × 0.488 mm × 0.75 mm in x, y, and z direction
respectively. The images were magnified in 5 times using cubic
B-spline interpolation, and line profiles were obtained
for each tube. To recover faithful line profile from the blurred images, the line profiles were deconvolved with a point
spread kernel of the MDCT which was estimated using the ideal tube profile and image line profile. The inner diameter,
outer diameter, and wall thickness of each tube were obtained with full-width-half-maximum (FWHM) method for the
line profiles before and after deconvolution processing. Results show that significant improvement was achieved over the
conventional FWHM method in the measurement of AWT.
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