Electro-Optical Monitoring of Trisodium Citrate Applicable in Haemodialysis

In this paper, we describe our initial steps in the development of online sensor to monitor the trisodium citrate concentration in extra-cerebral blood flow during haemodialysis. Accurate and fast monitoring would allow the regulation of the concentration of citrate returning to the human bloodstream to its original values, thereby, making the patient significantly less burdened than at present. In the early stages, we focused on the determination of concentration by measuring of electrical impedance and reflection in the collected blood. Our aim is to study the trends of influencing these signals by concentration and to develop a suitable methodology that can be used later in the sensor. In part, we begin working on the selectivity of the methodology that we would like to achieve by calculating the equivalent electrical model of the solution. It is based on the electrochemical double layer model and the corresponding Cole-Cole graphs.