Bullous pemphigoid associated with acquired hemophilia

daily for 1 week), pulse therapy with methylprednisolone (1000 mg/day for 3 days) and rituximab (100 mg/week for 2 weeks) were initially used for correcting the coagulopathy. Prednisolone (1 mg/kg/day) and cyclophosphamide (100 mg/ day) were prescribed as maintenance therapy. The coagulatory disorder improved after 2 months of treatment associated with reduction of factor VIII inhibitor to 35 Bethesda units/mL with concomitant improvement of ecchymosis (Figure 3). A subsequent reduction in the factor VIII inhibitor level was observed and it was 3 Bethesda units/mL after 3 months of follow-up.