Исследование взаимосвязи полиморфных вариантов генов VEGF и MUC2 с риском развития эндометриоза

The aim of the study was to search for the association of the polymorphisms +936C/T and +460C/T of the VEGF gene and polymorphisms of C(-15161)T (rs10902088) and T(-12150)C (rs10794288) of the MUC2 gene with the risk of developing genital endometriosis in the Slavic population of the North-Western Federal District. The study included 60 patients (mean age 32.1 ± 12.4 years) with a diagnosis of external genital endometriosis and 76 healthy donors (mean age 29.6 ± 9.7 years). Genotyping was carried out by real-time PCR using the LightCycler 480 Instrument II (Roche, Switzerland) amplifiers and VEGF T(-460)C (rs833061), VEGF C936T (rs3025039), MUC2 C(-15161)T (rs10902088), MUC2 T(-12150)C (rs10794288) (Sintol). The association of C allele (OR = 2.11) and the СС genotype (OR = 2.57) of polymorphism rs833061460 in VEGFA gene with an increased risk of developing external genital endometriosis in Slavic population of the North-Western Federal District.