A simple asymmetric synthesis of 2-substituted pyrrolidines from 3-acylpropionic acids
1991
The title compounds have been prepared from 3-acylpropionic acids 2 and (−)-R-phenylglycinol in a three-step sequence in >98% enantiomeric excess. The R group in 2 ultimately becomes the 2-substituent in the chiral pyrrolidine
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