Pre-exposure of rat anterior pituitary cells to somatostatin enhances subsequent growth hormone secretion

The precise roles of GH-releasing factor (GRF) and somatostatin (SRIF) in the orchestration of pulsatile GH secretion have not yet been fully determined. We examined the interactions of rat GRF and SRIF, in the concentration ranges present in rat hypophysial portal blood, on the secretion of GH from dispersed male rat anterior pituitary cells in monolayer culture