[Serum levels of suppressor of cytokine signaling 3, tumor necrosis factor-alpha and interleukin-10 in preeclampsia mothers and their clinical values].

Objective To explore the serum levels of suppressor of cytokine signaling 3 (SOCS3), tumor necrosis factor-alpha (TNF-α) and interleukin-10 (IL-10) in preeclampsia mothers and determine their clinical values. Methods A total of 40 preeclampsia mothers at International Peace Maternity and Child Health Hospital of China Welfare Institute Affiliated to Shanghai Jiaotong University from March 2011 to August 2013 were enrolled into observation group. Another 40 cases of mothers without pregnancy complications were selected as control group. Then the serum contents of SOCS3, TNF-α and IL-10 were detected and their correlations analyzed. Results (1) The mRNA levels of SOCS3 of observation and control groups were 38±6and 100±16while the mRNA levels of TNF-α 226 ±40 and 100±19 respectively; (2) the proteins levels of SOCS3 of observation group were lower than those of control group (P<0.05) while the proteins levels of TNF-α of observation group were higher than those of control group (P<0.05); (3) the mRNA and protein contents of SOCS3 were negatively correlated with mRNA and protein contents of TNF-α and positively correlated with IL-10. Conclusion The serum content of SOCS3 decreases significantly in preeclampsia so that there is a down-regulation of Th1 type cytokine TNF-α and an up-regulation of Th2 type cytokine IL-10. And it may play an important role in the occurrence of disease. Key words: Preeclampsia; Interleukin-10; Tumor necrosis factor-alpha; Suppressor of cytokine signaling 3