Association of anticardiolipin antibodies with intraglomerular thrombi and renal dysfunction in lupus nephritis

Summary We studied positivity for anti-cardiolipin antibody, disease activity when compared with changes in the ACA-negative patients ( p<0.05 in all cases). There intraglomerular capillary thrombi on renal biopsy, and the progression of renal disease in 51 patients was no significant difference when patients were separated according to the presence or absence of (10 male and 41 female), mean age 37 years (range 17‐65 years), with a diagnosis of systemic lupus thrombi. Renal function at presentation was worse in patients with intracapillary thrombi and ACA erythematosis and clinically evident nephritis confirmed by renal biopsy. Serum creatinine, serum positivity (p=0.085 and p=0.042, respectively). All patients progressed, but only those with indicators of disease activity and biopsies were analysed in subgroups according to thrombi and intracapillary thrombi or anti-cardiolipin antibody positivity had a significant deterioration in renal anticardiolipin status. End-points were death or chronic dialysis requirement and survival. Degree function. Twenty-one thrombotic episodes occurred in 14 patients, of whom 13 were ACA-positive. Antiof sclerosis, crescent formation and necrosed glomeruli were all greater in those specimens positive cardiolipin antibody is a strong predictor of the presence of intraglomerular thrombi in SLE patients for thrombi and in those specimens of patients who were serum ACA-positive, suggesting a relationship with renal involvement. The presence of thrombi and/or anticardiolipin antibodies indicate a worse to disease activity/severity at presentation. The increase in serum anti-DNA antibodies and ANA long-term renal outcome. Anti-cardiolipin antibody positivity is a strong predictor of systemic vascular and the reduction in C3 and C4 were significant in ACA-positive patients, with a strong relationship to thrombotic complications.