A Novel Preparation of 3-Hydroxy-3H-indole-3-ethanamines and -3H-indole-3-acetamides Having either a 4-Morpholinyl or 1-Pyrrol-idinyl Group at the 2-Position

A novel synthetic method is discovered for 3-hydroxy-3H-indole-3-ethanamines and -3H-indole-3-acetamides having either a 4-morpholinyl or 1-pyrrolidinyl group at the 2-position by reacting the corresponding 1-hydroxyindoles with enamines in the presence of tosyl or mesyl chloride. A plausible mechanism is proposed.