Terpenoids isolated from Chinese liverworts Lepidozia reptans and their anti-inflammatory activity

Abstract Five new terpenoids ( 1 – 5 ) including two dollabellane-type, one ent -kaurane-type diterpenoids and two sesquiterpenoids were isolated from the Chinese liverwort Lepidozia reptans (L.) Dumort. , together with nine known terpenoids ( 6 – 14 ). Their structures were determined on the basis of analysis of MS and NMR spectroscopic data, single-crystal X-ray diffraction and electronic circular dichroism calculations. The selected compounds 1 , 2 , 6 , 7 , 9 and 14 were screened for anti-inflammatory activities by the model of LPS-induced nitric oxide (NO) production with macrophage cells, and the mechanism of the active compounds 1 and 2 were further explored.