Pd-Catalyzed Coupling Reaction of Fluorinated Propargyl Amidines with Aryl Iodides

Catalyzed by ligand free Pd(OAc)2, 2,5-disubstituted imidazole was prepared in good yield by the reaction of fluorinated propargyl amidines with iodoarene. Mechanistic studies indicated that this transformation occurs through a nitropalladation–reductive elimination pathway.