LIPID PEROXIDATION IN PATIENTS WITH COPD AND CHRONIC HEART FAILURE.

Body: For modern medicine the comorbid course of many diseases is characteristic, for example, chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF). Pathogenetically, each of these diseases is accompanied by the development of oxidative stress. Objective: to estimate levels of lipid peroxidation in patients with isolated and comorbid pathology of COPD and CHF. Methods: The study included 45 patients, divided into 3 groups: 1- patients with COPD, 2 - patients with CHF, 3 - patients with comorbid course of COPD and CHF. Intensity of peroxidation was measured by the levels of molecular products of lipid peroxidation: the level of conjugated dienes and trienes (CD, CT), Schiff bases (SB). Theresults are presented as Me [Q1; Q2], where Me is the median, [Q1; Q2] - 95% confidence interval. Results: A confirmation of the activation of oxidative stress was an increase in the levels of lipid peroxidation products: the CD (r.u.): in COPD group was 0.226 [0.194; 0,258], in CHF group - 0,245 [0.214; 0.276], in group COPD and CHF - 0.265 [0.218; 0.313], p = 0.6083; the index of CT (r.u.): in group 1 - 0.186 [0.139; 0.234], in 2nd group - 0.203 [0.157; 0,248], in 3rd group - 0,248 [0.218; 0.313] p = 0.5772. There were no statistically significant differences in the levels of SB between groups (p = 0.7104). The obtained data indicate a high intensity of free radical reactions and the formation of primary products of lipid peroxidation in all comparable groups without statistically significant differences, which indicates similar pathogenetic processes of COPD and CHF and determines the severity of their comorbid course.