Neuroimage in Alzheimer's disease: Results after plasma exchange with Human Albumin Grifols®

Further, MCI patients also showed decreased BOLD signal in the hippocampus during the delay period when compared to controls. Although MCI patients had diminished neural activity, they performed similarly to controls on the delayed yes/no recognition task. However, in a surprise, incidental longterm memory task, MCI patients reported less familiarity with the previously viewed pictures than controls. Conclusions: Taken together, these findings suggest that MCI patients were unable to adequately modulate neural activity in critical task-specific brain regions for attention and memory, and thereafter demonstrated impaired long-term memory recognition. In summary, the DLPFC and the hippocampus may be sites of early selective vulnerability in MCI patients, and that differences in neural modulation may be a potential biomarker of mild cognitive impairment.