Quadruple Regimens for Helicobacter pylori Infection

An effective therapy against Helicobacter pylori (H. pylori) is defined as one achieving at least a 90 % eradication rate. Treatment results are best when reliable schemes are based on susceptibility testing; however, empiric eradication therapies are generally prescribed. Standard triple therapy has been the most recommended regimen, but its efficacy is currently suboptimal worldwide due to rising clarithromycin resistance. Consequently, the scientific community has recently taken on the task of rescuing old empiric quadruple regimens to overcome antibiotic resistance.