tricyclic dual inhibitors of CDK 4/6 condensates and FLT3

Compound of formula I: ** ** Formula or a pharmaceutically acceptable salt thereof, a hydrate thereof or a mixture thereof, wherein: R1 is a group of formula IA, formula IB, formula IC or formula ID ** ** formula in which the symbol indicates the point of attachment of the group of formula IA, IB, IC or ID to the remainder of the molecule; R2 is a C5-C7 cycloalkyl group, a heterocyclyl group is 5 to 7 members including 1, 2 or 3 heteroatoms selected from N, O and S or a bicyclic C7-C10; wherein the C5- C7 cycloalkyl group, the heterocyclyl group of 5 to 7 members or C7-C10 bicyclic group is unsubstituted or substituted with 1-3 substituents independently selected from - (C1-C6) alkyl, - OH, halo, -O- (C1-C6) alkyl, -CO2H, -C (> = O) -O- (C1-C6), -C (> = O) -NR'R ", -NR' R "or - (C1-C4) alkyl, wherein the - (C1-C4) is substituted with 1-3 substituents independently selected from halo, -OH, -OCH3, -S (> = O) 2-CH3 or -C (> = O) -CH3; R3a is selected from -H, -F or -Cl, - (C1-C3) or -O- (C1-C3); R3b is -H, halo, -OH, -O- (C1-C6), - (C1-C6) alkyl, -NR'R ", -C (> = O) - (C1-C6) , -C (> = O) -O- (C1-C6 alkyl), -C (> = O) -NR'R "or - (C1-C6) alkyl, wherein the - (C1- alkyl C6) alkyl is substituted with 1-3 substituents independently selected from halo, -OH, -OCH3, -CN or -NO2; R3c is -H, - (C1-C3) or halo; R4 is -H; R5 is -H; R6 is selected from -H, - (C1-C6), -C (> = O) - (C1-C6), -C (> = O) -O- (C1-C6), -C ( > = O) -C (> = O) -OH, -C (> = O) NR'R "or -S (> = O) -NR'R", in which the alkyl group of the groups - (C1-C6 alkyl), -C (> = O) - (C1-C6 alkyl) and C (> = O) -O- (C1-C6) is unsubstituted or substituted with 1-3 substituents independently selected -OH, F, -S (> = O) 2- (C1-C6) alkyl, -O- (C1-C6) alkyl, -NR'R "or -CN; R7a is-H, -CH3 or halo ; R7b is -H, - (C1-C6) alkyl or halo; or R 7b is absent if R1 is a group of formula IB or formula ID; R7c is -H, - (C1-C6) alkyl, halo, - O- (C1-C6), -NO2, -CN, -NR'R ", -CO2H, -C (> = O) -O- (C1-C6), -C (> = O) -NR 'R "or - (C1-C6) alkyl, wherein the - (C1-C6) alkyl is substituted with 1-3 substituents independently selected from -OH, halo, -O- (C1-C6) , -CN, -NR'R "or -S (> = O) 2-CH3; or R7c is absent if R1 is a group of formula IA or formula IC; R8a is -H, - (C1-C6) alkyl or - (C1-C6) alkyl, wherein the - (C1-C6) alkyl is substituted with 1-3 substituents independently selected from -OH, halo or -O- (C1-C6); R8b is -H, - (C1-C6) alkyl or - (C1-C6) alkyl, wherein the - (C1-C6) alkyl is substituted with 1-3 substituents independently selected from -OH, halo or -O- (C1-C6); or R8a and R8b, when taken together, can represent> = O; 8c is selected from -H, -OH, - (C1-C6) alkyl or - (C1-C6) alkyl, wherein the - (C1-C6) alkyl is substituted with 1-3 substituents selected independently -OH, halo or -O- (C1-C6); 8d is -H, - (C1-C6) alkyl or - (C1-C6) alkyl, wherein the - (C1-C6) alkyl is substituted with 1-3 substituents independently selected from -OH, halo or -O- (C1-C6); 8e is -H, - (C1-C6) alkyl or - (C1-C6) alkyl, wherein the - (C1-C6) alkyl is substituted with 1-3 substituents independently selected from -OH, halo or -O- (C1-C6); 8f is -H, - (C1-C6) alkyl or - (C1-C6) alkyl, wherein the - (C1-C6) alkyl is substituted with 1-3 substituents independently selected from -OH, halo or -O- (C1-C6); 8e and 8f or, when taken together, they can represent> = O; and R 'and R "are independently selected from -H, - (C1-C4) alkyl or - (C1-C4) alkyl substituted with 1 to 3 substituents independently selected from -OH or -F.