Synthesis and biological evaluation of novel rigid 1,4-benzodiazepine-2,5-dione chimeric scaffolds
2008
Novel, conformationally constrained 1,4-benzodiazepine-2,5-diones containing both a monosaccharide, fructose, and a proline moiety have been synthesized as chimeric scaffolds; preliminary biological evaluation as GABAA receptor ligands is reported. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
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