Transmission of NS5A resistance associated substitutions among men-who-have-sex-with-men recently infected with hepatitis C virus genotype 1a

Transmission of direct-acting antiviral(DAA) resistance associated substitutions(RAS) could hamper hepatitis C virus (HCV) cure rates and ultimately jeopardize elimination efforts. A phylogenetic analysis of 87 men-who-have-sex-with-men recently infected with HCV genotype 1a demonstrated that one-third(28/87) belonged to a single large cluster in which 96% harbored the NS5A M28V RAS.