Prevalence of Hyperuricemia and Its Relationship with Kidney Injury among Urban and Rural Population in Guangxi

Objective To study the prevalence of hyperuricemia(HUA) among urban and rural populations in Guangxi and to investigate the relationship between HUA and kidney injury. Methods Stratified multistage random sampling method were applied and 18 to 74 years old residents from both urban and rural areas in Guangxi were surveyed.All subjects were evaluated by questionnaire and underwent blood uric acid,serum creatinine,fasting blood glucose,total cholesterol,triglyceride,urinary albumin/creatinine ratio,hematuria(microscopic examination of centrifuged urine sediment) and kidney B-mode ultrasound examinations.Glomerular filtration rate(eGFR) was calculated by the simplified MDRD formula corrected with Chinese people. Results Prevalence of HUA was higher in urban population than in rural population in all age groups(P0.05),with the exception of females of the 18～29 age group.The prevalence of HUA was 16.00% in urban and rural population in Guangxi.The prevalence of HUA in urban population was significant higher than that in rural population(19.78% vs 12.31%,P0.05),higher in man than in woman(20.39% vs 11.59%,P0.05).Systolic blood pressure,diastolic blood pressure,serum creatinine,fasting blood glucose,total cholesterol,and triglyceride were higher in HUA population than in non-HUA population(P0.05).The incidence rates of albuminuria,decreased of renal function,renal stones and chronic kidney disease were 8.86%,9.35%,15.21% and 7.79% in HUA population and 4.94%,3.60%,8.07% and 6.83% in non-HUA population(P0.05). Conclusion The prevalence of HUA in Guangxi is 16.00%.The prevalence of HUA is significantly higher in urban population than in rural population.HUA is an independent risk factor of kidney injury.