Effects of trimetazidine on plasma level of brain natriuretic peptide and clinical value of BNP in patients with chronic heart failure

Objective To observe the effects of trimetazidine on changes of plasma brain natriuretic peptide(BNP)and the clinical value of BNP in the diagnosis of chronic heart failure(CHF).Methods Sixtyeight patients with CHF were randomly divided into trimetazidine group and the conventional group,patients in the trimetazidine group were given trimetazidine 20 mg,tid,for 4 weeks.NYHA functional class,plasma BN-Pand echocardiographic indices(LVEDD,LVMI,LVEF)were evaluated before and after 4 weeks'therapy.Results After 4 weeks therapy,compared with the patients in the conventional group,trimetazidine improve cardiac function and reduce the Ievel of plasma BNP significantly.Conclusion Trimetazidine might improve cardiac function and reduce the level of plasma BNP in CHF patients,and plasma BNP might serve as a good indicator for evaluation of CHF and therapy in CHF patients. Key words: Heart failure; Trimetazidine; Brain natriuretic peptide