THE DETECTION OF FRACTAL DIMENSION WITH PROTECTIVE EFFECTS OF LYCOPENE AND CATECHIN CARBON TETRACHLORIDE-TREATED RAT'S LIVER

KARBON TETRAKLORUR UYGULANMIŞ SICAN KARACIĞERINDE LIKOPEN VE KATEŞININ KORUYUCU ETKILERININ FRAKTAL BOYUTUNUN SAPTANMASI Ozet : Amacimiz karbon tetraklorur uygulanmis sican karacigerinde likopen ve katesinin koruyucu etkilerinin fraktal boyut hesaplamasi kullanilarak ortaya konmasidir. Fraktal boyut nesnenin yogunlugunu ve karmasikligini olcer. Sicanlar; sivi yag, likopen, katesin, karbon tetraklorur + likopen, karbon tetraklorur + katesin ve karbon tetraklorur olmak uzere alti gruba ayrildi. Doku ornekleri 21. gun sonunda elde edildi. Karaciger dokusundaki harabiyet, hematoksilen ve eozin boyama ile degerlendirildi. Hepatosit bolgeleri isik mikroskobu altinda kucuk karelere ayrildi. Sonra en az bir nukleusun bir kareyle kesistigi alan sayildi.  Fraktal boyut ln(N(n))/ln(2 n ) formulle hesaplandi. Ozellikle, fraktal boyut degerleri acisindan kontrol ve katesin ile tedavi edilen gruplar arasinda bir fark yoktu. Ama likopen degerleri kontrol ve katesin uygulanan sicanlarda daha yuksek bulundu. Karbon tetraklorur uygulanmis sicanlarda fraktal boyut dusuktu. Karbon tetraklorur uygulanmis gruba gore karbon tetraklorur + likopen ve karbon tetraklorur + katesin gruplarinda fraktal boyutta artis gozlendi. Bulgular hepatosit miktarindaki azalmain, fraktal boyutun azalmaya neden olacagini gostermistir. Diger taraftan, karbon tetraklorur hepatositlerin az olmasi nedeniyle fraktal boyutu azaltmistir. Katesin ve likopen uygulanan gruplarda yuksek hepatosit miktarina bagli olarak fraktal boyutta artis goruldu. Bu calisma fraktal boyut kullanilarak tip ve matematigi birlestirmektedir. Bu hesaplamalar dogrultusunda,  antioksidan maddelerin toksisite ve koruyucu etkisi tespit edilebilir.  Anahtar Kelimeler : CCl4, likopen, katesin, fraktal boyut THE DETECTION OF FRACTAL DIMENSION WITH PROTECTIVE EFFECTS OF LYCOPENE AND CATECHIN CARBON TETRACHLORIDE-TREATED RAT'S LIVER Abstract : Our aim is to investigate the detection of fractal dimension (Box-counting dimensions) with protective effects of lycopene and catechin in carbon tetrachloride-treated rat's liver. Fractal dimension measure intensity and complexity of subject. The rats were divided into six groups as liquid oil, lycopene, catechin, carbon tetrachloride plus lycopene, carbon tetrachloride plus catechin and carbon tetrachloride. The tissue samples were obtained at end of 2Ist day. The liver tissue distortions were evaluated using hematoxylin and eosin staining. The regions of hepatocyte were separated into small square under light microscopy. Then, counted at least one nucleus with intersection of one square. Fractal dimension were determined by using this formula; ln(N(n))/ln(2 n ). Notably, there was no differences between control and catechin-treated rats on fractal dimension values. But, lycopene values was bigger than control and catechin administrated rats. In carbon tetrachloride-treated rat, fractal dimension is less. It was increased in lycopene plus carbon tetrachloride and cate­chin plus carbon tetrachloride with compare to carbon tetrachloride group. The findings confirmed, if hepatocyte is less, fractal dimension will decrease On other hand, carbon tetrachloride decreased fractal dimension due to less hepatocyte. It was increased in fractal dimension due to high hepatocyte in catechin and lycopene treated rats, because of their protective effects. This study is combination of medicine and mathematics, as fractal dimension. It was calculated, toxicity and protective effects of antioxidant materials could be determined in this way. Key words: : CCl4, Lycopene, catechin, Fractal dimension