Right Ventricular Failure in Patients Requiring Mechanical Circulatory Assistance Is Associated with Elevated miR-15b Expression

Fourteen miRNA transcripts were quantified following reverse transcription and realtime polymerase chain reaction; expression levels were normalized to an internal control. After testing for normality, group comparisons were performed using a ttest. ROC curves were generated to evaluate diagnostic utility of miRNA expression. Results: No age or gender association was observed with any miRNA expression. Of 14 miRNA tested, 6 were significantly associated with ISHF, 5 with ID-HF and 4 with both (Table 1). By ROC analysis miRNA expression robustly differentiates HF groups from HC (Table 2).