Are There Reliable Biomarkers for Immunosenescence and Inflammaging

Aging is accompanied by changes in the immune system, culminating in immunosenescence on one hand and inflammaging on the other. Science is striving for biomarkers to capture these heterogenous complex processes. However, when the basic interpretation does not capture correctly the underlying phenomenon, the biomarkers may not be accurate either. Thus, we tried to give a new interpretation of the immune changes with aging as mostly adaptative (and even partially beneficial) in physiological circumstances. So we need new biomarkers which could capture these novel concepts this new reality concomitantly to the old ones. Finding and applying them would in our opinion result in a better modulation of the immune changes in elderly subjects.