Abstract 17051: Relationship Between Neurohormonal Blockade Dose and Clinical Outcome in Patients With Heart Failure With Recovered Ejection Fraction

Introduction: Heart failure (HF) patients who recover left ventricular function (HF-Recovered) have reported to have a different prognosis compared to HF with reduced or preserved ejection fraction (EF). However, no study has analyzed the dosage of neurohormonal blockade in these patients. Hypothesis: Higher dose of neurohormonal blockade might be important for better outcomes in HF-Recovered patients. Methods: HF-Recovered patients were defined with left ventricular EF ≥40% at time of study entry and retrospectively checked EF <40%. 256 patients were enrolled between Mars 2009 and September 2014. Results: Of the study population, 48.8% received <50% of the target dose of angiotensin-converting enzymes inhibitors (ACEIs)/angiotensin-receptor blockers (ARBs), whereas 51.2% received ≥50% of the target dose at time of EF ≥40%. 55.5% received <50% of the target dose of β-blockers (BBs), whereas 44.5% received ≥50% of the target dose. 31.3% increased the dose of ACEIs/ARBs or BBs at time of EF ≥40% (uptitratio...