New peptide Actinomadura namibiensis
2009
The invention relates to a compound of formula (I), wherein R3 and R4 independently represent H or OH, and m and n independently of one another 0, 1 or 2, obtainable from Actinomadura namibiensis (dSM 6313). The invention also relates to the use of this compound in the treatment of bacterial infections, viral infections and / or pain, as well as pharmaceutical compositions containing it. The compounds of formula (i) have been defined as labyrinthopeptines and have a high bridged peptidic structure of 18 amino acids containing lanthionine-like residues and similar amino acid alpha-disubstituted. The amino acid sequence is xdwxlwexcxtgxlfaxc, wherein the two Cys residues form a disulfide bridge and each X independently represents a non-natural amino acids involved in the bridging linkages.
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