Terpenoids from Euphorbia micractina

From an ethanol extract of Euphorbia micractina roots, sixteen terpenoids were isolated by a combination of various chromatographic techniques, including column chromatography over macroporous resin, silica gel, and Sephadex LH-20 and reversed-phase HPLC. Their structures were elucidated by spectroscopic data analysis as loliolide myristate(1), 24-methylenetirucall-8-en-3β,11α-diol-7-one(2), loliolide(3), 3β-hydroxy- 5α,6α-epoxy-7-megastigmen-9-one(4), jolkinol A(5), jolkinol D(6), latilagascene F(7), helioscopinolide A(8), helioscopinolide B(9), 3-O-acetylhelioscopinolide B(10), helioscopinolide D(11), helioscopinolide E(12),(+)-11-acetoxyatis-16-en-3,14-dione(13), erythrodiol(14), uvaol(15) and betulin(16). All of the compounds were obtained from this plant for the first time, in which 1 and 2 are new compounds.