Haemostatic abnormalities and clinical findings in Vipera palaestinae-envenomed dogs.

Abstract The venomous viper Vipera palaestinae ( Vp ) is responsible for most envenomations in humans and animals in Israel. Its venom contains proteases, haemorrhagins, l -amino acid oxidase and phospholipase A 2 but its effects on haemostasis have yet to be characterised. This prospective study aimed to characterise haemostatic abnormalities in Vp -envenomed dogs from presentation to discharge or death, and their association with mortality. Samples from 39 Vp -envenomed dogs were collected periodically and examined for haematology, prothrombin time (PT), activated partial thromboplastin time (aPTT), antithrombin activity (ATA), fibrinogen level and D-dimer concentration. All dogs presented with severe local signs and most (79%) had systemic signs. Six dogs (15%) died. Haemostatic abnormalities were present in 37/39 dogs. Increased D-dimer concentrations were detected in 28/31 dogs. Disseminated intravascular coagulation was diagnosed in 10 dogs and in all non-survivors. Platelet and leucocyte counts at presentation, maximum PT and aPTT, and minimum ATA during hospitalisation were significantly different between survivors and non-survivors and were good predictors of the outcome. The results show that hypercoagulability, consumption and derangement of haemostasis are common in Vp -envenomed dogs and are associated with mortality. Haemostasis should be closely monitored in such dogs.